Cellular Senescence in Bone

Senescence is an irreversible cell-cycle arrest process induced by environmental, genetic, and epigenetic factors. An accumulation of senescent cells in bone results age-related disorders, one the common problems osteoporosis. Deciphering basic mechanisms contributing to chronic ailments aging may uncover new avenues for targeted treatment. This review focuses on most relevant research advancements skeletal cellular senescence. To identify options treatment or prevention diseases, researchers have hallmarks aging, including telomere attrition, genomic instability, senescence, alterations. First, this chapter provides overview fundamentals tissue, causes involution, role senescence diseases such as Next, will discuss utilization pharmacological interventions tissues and, more specifically, highlight effective safe strategies.